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DNA Ligases

Enzymes joining DNA termini in the cell nucleus. DNA ligase I (125 kDa) is the most important ligase in animal cells, DNA ligase II (72 kDa) and DNA ligase III (100 kDa) have minor role in mammalian cells. DNA ligase IV mediates joining of the ends of DNA in eukaryotic non-homologous recombination. Other organisms have different DNA ligases. Bloom's syndrome and acute lymphoblastic