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DNA Kinking

The regulation of transcription depends on protein-induced localized modification of the DNA structure (bending). This modification depends on the nature of the proteins recruited for the tasks and the base sequences in the DNA. The bases stacked in the major and minor grooves ('the rungs') of the helix may cause four major categories of architectural alterations relative to each other: (1) twist [slight rotation of the rung], (2) roll [slightly lifting the broader side of a rung],