ABL (Abelson murine leukemia virus oncogene)

Located to human chromosome 9q34.1 and mouse chromosome 2. When translocated to human chromosome 22 it may transcribe a fusion protein with an abnormal protein tyrosine kinase activity, which is probably the cause of chronic myeloid leukemia. Acute lymphocytic leukemia is also associated with a similar translocation, the Philadelphia chromosome, but it appears that tyrosine kinase activation is different from that of the fusion protein. The ABL gene has about 300-kb intron down-stream from the first exon. This intron appears to be the target of the translocations and causes acute lymphocytic