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Progressive lipodystrophy

Synonym(s)

Definition

Disorder characterized by progressive and symmetric loss of subcutaneous fat

Pathogenesis

May be associated with glomerulonephritis, low C3 levels, and the presence of a C3 nephritic factor

Clinical manifestation

Onset between 5 and 15 years of age; slow, insidious loss of subcutaneous fat, initially limited to the