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Arachidonic acid metabolites

Synonyms

AA metabolites, eicosonoids, PGG2 , prostaglandin G2 , PGH2 , prostaglandin H2 , PGE2 , prostaglandin E2 , PGF , prostaglandin F , thromboxane A2 , TXA2 , prostacyclin, PGI2 , 5-HPETE, 15-HPETE, lipoxins, lipoxin A4, lipoxin B4, leukotriene A4 , LTA4 , leukotriene B4 , LTB4 , leukotriene C4 , LTC4 , leukotriene D4 , LTD4 , leukotriene E4 , LTE4 .

Definition

Biologically active products of the enzymatic cascade whereby cyclooxygenases (PGH synthases) and 5-lipooygenase incorporate arachidonic acid as the initial substrate. Subsequent sequential enzymatic reactions yield biologically active prostaglandins and leukotrienes.

Full Text

Following phospholipase mediated liberation of arachidonic acid from cell membrane phospholipids, arachidonic acid may be metabilized by cycooxygenase (PGH synthase) to yield PGG2; subsequent peroxidase activity yields PGH2 which may then be used as a substrate by specific prostaglandin synthases to yield