Arachidonic acid metabolites

Synonyms

AA metabolites, eicosonoids, PGG₂ , prostaglandin G_{2 ,} PGH₂ , prostaglandin H₂ , PGE₂ , prostaglandin E₂ , PGF_2α , prostaglandin F_2α , thromboxane A₂ , TXA₂ , prostacyclin, PGI_{2 ,} 5-HPETE, 15-HPETE, lipoxins, lipoxin A4, lipoxin B4, leukotriene A₄ , LTA₄ , leukotriene B₄ , LTB₄ , leukotriene C₄ , LTC₄ , leukotriene D₄ , LTD₄ , leukotriene E₄ , LTE_{4 .}

Definition

Biologically active products of the enzymatic cascade whereby cyclooxygenases (PGH synthases) and 5-lipooygenase incorporate arachidonic acid as the initial substrate. Subsequent sequential enzymatic reactions yield biologically active prostaglandins and leukotrienes.

Full Text

Following phospholipase mediated liberation of arachidonic acid from cell membrane phospholipids, arachidonic acid may be metabilized by cycooxygenase (PGH synthase) to yield PGG₂; subsequent peroxidase activity yields PGH₂ which may then be used as a substrate by specific prostaglandin synthases to yield