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Scope of Alkaloids in Antileishmanial Drug Discovery and Development

Introduction
Taxonomy of Leishmania spp.
Parasite Biology
Drug Targets
Sterol Biosynthetic Pathway
Glycolytic Pathway
Nucleoside Transporters
Purine Salvage Enzymes
GPI Biosynthetic Pathway
Proteinases as Drug Targets
Folate Biosynthesis
Glyoxalase System
Topoisomerases
Hypusine Pathway
Bioavailability and Metabolism
Current Chemotherapy of Leishmaniasis
Pentavalent Antimonials
Pentamidine
Amphotericin B
Miltefosine
Paromomycin
Other Drugs
Natural Products as Folk Medicines Against Leishmaniasis
Alkaloids
Benzo[c]phenanthridine Alkaloid
Quinoline Alkaloids
Furoquinoline Alkaloids
Isoquinoline Alkaloids
Naphthylisoquinoline Alkaloids
Bisbenzylisoquinolinic Alkaloids
Indole Alkaloids
Steroidal Alkaloids
Benzoquinolizidine Alkaloids
Diterpene Alkaloids
Pyrrolidinium Alkaloids
Acridone Alkaloids
β-Carboline Alkaloids
Alkaloids from Marine Sources
Future Perspectives
References

Abstract