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Oxyacanthine

CAS Registry Number: 548-40-3 MediaObjects/978-1-4614-0560-3_7_Part_Fig1-738_HTML.gif

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids - Bisisoquinoline Alkaloids

Biological sources: Berberis amurensis, B. crataegina, B. densiflora, B. heteropoda, B. iliensis, B. integerrima, B. nummularia, B. oblonga, B. thunbergii, B. turcomanica, B. vulgaris, Mahonia aquifolia

C37H40N2O6: 608.2886

Mp: 206-208°C (EtOH) [1], 216-217°C (Et2O) [1]

[α]D +279° (CHCl3) [1]

UV: 206, 238 sh, 282(4.94, 5.45, 3.92) [2]

MS m/z: 608(M+), 607, 501, 417, 416, 396, 395, 381, 364, 349, 335, 304(++), 198(++, 100), 192, 175(++), 174 [3]

1 H NMR: 2.56(2-NCH3), 2.66(2′-NCH3), 3.18(7′-OCH3), 3.63(H-1, 6-OCH3), 3.79(6′-OCH3), 4.19(H-1′), 5.43(H-10), 6.31(H-5′), 6.34(H-11′), 6.35(H-5), 6.63(H-8), 6.76(H-14), 6.78(H-13), 6.94(H-13′), 6.98(H-10′) [4]

Pharm./Biol.: LD50 43.5 mg/kg (i/v, mice). Hypotensive [6], antimycotic [5], depressive