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Tumors of the Retinal Pigment Epithelium :Congenital Hypertrophy of the RPE (CHRPE)

Synonyms

Retinal nevus

Benign melanoma of the RPE

Bear tracks

Polar bear tracks

Atypical CHRPE

Pigmented ocular fundus lesion (POFL)

Definition

Congenital hypertrophy of retinal pigment epithelial cells.

Etiology

The etiology of CHRPE is unknown but it is believed to be a congenital lesion.

Clinical Presentation

CHRPE is a flat, pigmented lesion with sharp borders at the levels of RPE.  They are usually unilateral with round, dark pigmentation, but can contain areas of hypopigmentation or depigmentation known as lacunae (Figure 1).  They can also be completely depigmented in rare instances.  Solitary CHRPE are isolated findings with no known systemic associations.  CHRPE can be seen in groups, commonly occurring unilaterally in a single sector.  These lesions are called bear tracks because of their resemblance to paw prints. Like CHRPE, bear tracks are not associated with systemic conditions.