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Transcription is the synthesis of an RNA chain by copying a complementary DNA strand of a particular gene (or cluster of genes in bacterial operons). Both in prokaryotic and eukaryotic cells, a DNA template is required for transcription as well as the four ribonucleoside triphosphates (ATP, GTP, CTP, and UTP) acting as substrates, and the enzyme RNA polymerase. As a result, a molecule of RNA (mRNA, tRNA, or rRNA) is produced. The initiation of transcription