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Germ Cell Tumors of the Ovary

Clinical and Pathologic Features of Germ Cell Tumors
Clinical and Pathologic Features of Tumors Composed of Germ Cells and Sex Cord-Stromal Derivatives


Germ cell tumors are composed of a number of histologically different tumor types derived from the primitive germ cells of the embryonic gonad. The concept of germ cell tumors as a specific group of gonadal neoplasms has evolved over the last several decades. It is based on (1) the common histogenesis of these neoplasms, (2) the relatively frequent presence of histologically different neoplastic elements within the same tumor, (3) the presence of histologically similar neoplasms in extragonadal locations along the line of migration of the primitive germ cells from the wall of the yolk sac to the gonadal ridge [253], and (4) the remarkable homology between the various tumors in the male and the female. In no other group of gonadal neoplasms is this homology