Phosphatidylinositol 3-kinase (PI3-Kinase)
The PI3-Kinase pathway is one of many signaling pathways that are important for cell growth, transformation, adhesion, apoptosis, survival and invasion. PI3-Kinases themselves are heterodimeric lipid kinases composed of catalytic and adaptor/regulatory subunits encoded by separate genes and alternative splicing. The PI3-Kinase enzyme family is organized under three main classes (class I, II and III) and various subgroups have been categorized based on their primary structure, substrate specificity and regulation.
The PIK3CA oncogene encodes for the alpha catalytic subunit and along with the p85 regulatory subunit,