Immunoglobulin Genes

Definition

Cluster in multimember gene families and are located on chromosome 14 (heavy chain gene segments), 2 (κ light chain) and 22 (λ light chain): V genes (variable region genes), D genes (diversity region genes) and J genes (joining region genes) for the heavy Ig heavy chains, V and J region genes for κ and λ light chains. Ig gene rearrangement brings together one representative of these gene families (V, D and J for the heavy chain, V and J for κ and λ light chains). V(D)J recombination