CBP/p300

Definition

Cyclic AMP response element- binding protein (CBP) and its homologue p300 are transcriptional co-activators of various sequence-specific transcription factors that are involved in a wide array of cellular activities, such as DNA repair, cell growth, differentiation and apoptosis. The ability of CBP/p300 to activate transcription resides in its capacity to acetylate the core histone proteins associated with enhanced promoter regions of the