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p75 Receptor

Definition

P75 is the low-affinity nerve growth factor (NGF) receptor that binds and internalizes nerve growth factor (NGF), neurotrophin-3 (NT-3) and brain derived neurotrophic factor (BDNF). It is normally expressed in sensory neurones, mainly of small diameter, and on the terminals of sympathetic and small sensory neurones in peripheral tissues such as skin and vascular muscle. These target tissues produce