Thyroid Nodules, Cold
Definition and Characteristics
Thyroid Nodules, Cold. Figure 1 The lack of scintigraphic Technetium uptake in CTNs correlates with a lack of NIS cell membrane insertion, (a) Scintigraphy, (b) NIS localized in the cell membrane of hot nodule, (c) NIS localized intracellularly in cold nodule.
Approximately 85% of all thyroid nodules are cold thyroid nodules (CTNs) . The large majority of them are benign and ∼5% of all nodules are malignant . The prevalence may vary geographically with iodine supply.
In agreement with the decreased scintigraphic uptake, a defective cell membrane targeting of NIS has been reported for CTNs . Moreover, a markedly increased proliferation, increased expression of histone mRNAs and cell