Tachycardia, Polymorphic Ventricular, Stress-induced
Catecholaminergic polymorphic ventricular tachycardia; Catecholaminergic bidirectional ventricular tachycardia; Familial polymorphic ventricular tachycardia; Ryanodine receptor mediated ventricular tachycardia
Definition and Characteristics
Mutations of the RYR2 gene are rare in a general Italian population. However, a mutation in RYR2 was found in 14 of 30 probands with exertion induced polymorphic ventricular tachycardia in the absence of structural heart disease . To date, more than 40 RyR2 mutations have now been found to be associated with stress-induced ventricular tachycardia [1-4].
RYR2 gene coding for the cardiac ryanodine receptor,