Biomedical and Life Sciences > Encyclopedia of Molecular Mechanisms of Disease > Pentalogy of Fallot
Redirected from: Tetralogy of Fallot with Atrial Septal Defect
Pentalogy of Fallot
Tetralogy of Fallot (TOF) with atrial septal defect (ASD) or patent foramen ovale (PFO)
Definition and Characteristics
Pentalogy of Fallot is a congenital heart defect with five anatomical components:
- Ventricular septal defect (VSD) consists of an unrestricted large anterior, subaortic perimembranous malalignment. It leads to equalization of right and left ventricular pressures.
- Right ventricular outflow tract obstruction (pulmonary stenosis, PS); infundibular (subvalvular) stenosis is found in all patients and may be accompanied by valvular and supravalvular stenosis. The patient's clinical picture and prognosis is most affected by the degree of pulmonary stenosis. It is more severe when the pulmonary valve is atretic.
- Right ventricular hypertrophy is not an anatomical pathology and develops secondary to pulmonary stenosis.
- Overriding of the aorta over the septal defect, due to a malalignment type of VSD. Part of the aorta exits